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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Rev Med Virol. 2009 May;19(3):147–164. doi: 10.1002/rmv.611

Figure 4. Models of translocation of HCMV pUL37x1\vMIA protein from the MAM to the OMM.

Figure 4

Detail of the proximity between the MAM and mitochondria is shown. The lipid enriched membrane of the MAM is represented (blue region) in the membrane. Complexes stabilizing the ER-mitochondrial contacts (PACS-2, Mfn2, and IP3R-Grp75-VDAC) are represented as well. Tethers observed by Csordas et al. [22] may serve as sites for direct transfer of pUL37x1\vMIA. Alternatively, lipid rich membrane domains may be distorted allowing close proximity between the membranes and the generation of vesicles/microvesicles or as lipid rafts that may traffic to the OMM. The key of the symbols is at the bottom of the figure.