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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2014 Sep 29;55:107–127. doi: 10.1146/annurev-pharmtox-010814-124915

Figure 5.

Figure 5

A personalized medicine plan for Asian Americans with the ALDH2*2 variant. The goal is to create a focus on preventative care, surveillance, and management while incorporating a clinical-translational approach for further research. Preventative care should focus on raising community and physician awareness in addition to implementing one-to-one patient counseling. Surveillance measures such as screening for high-risk diseases should occur, and awareness when physicians perform surgical procedures for those with the ALDH2*2 variant should be stressed. Additional scientific studies are needed that use translational research tools with platforms like the Stanford Translational Research Integrated Database Environment (STRIDE), biomarkers, and additional genome-wide association studies (GWAS), particularly for Asian Americans. In addition, translational basic science studies are needed in relevant models such as the ALDH2*2 knock-in mouse and how chemical compounds, including Alda-1, mechanistically modify disease.