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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Virology. 2001 Oct 25;289(2):208–217. doi: 10.1006/viro.2001.1112

FIG. 2.

FIG. 2

L95R replication/pathogenesis was impaired in the SCID-hu Thy/Liv mouse. (a) HIV-1 replication in SCID-hu Thy/Liv mice. SCID-hu Thy/Liv mice were infected with equivalent infectious units of NL4-3 or L95R. Virus replication (p24, pg/106 thymocytes) was monitored following infection. The data are representative of three independent experiments with 8–10 SCID-hu Thy/Liv mice for each virus. Error bars represent standard errors. (b) HIV-1 pathogenesis in SCID-hu Thy/Liv mice. Pathogenesis was determined by the percentage of total CD4+ (CD4+CD8+ and CD4+CD8−) thymocytes. Values for NL4-3- and L95R-infected Thy/Liv organs are presented relative to the mock-infected Thy/Liv organ (set as 100%). Error bars represent standard errors from 8–10 SCID-hu mice. (c) A representative FACS analysis of CD4/CD8 staining is shown to illustrate the relative thymocyte depletion by NL4-3 and L95R at 4 wpi in comparison to mock infection.