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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Alcohol. 2014 Aug 7;48(6):579–586. doi: 10.1016/j.alcohol.2014.07.006

Fig 2.

Fig 2

Ethanol interacts synergistically with cocaine to produce C-shape movements in planarians. 2A) Effects of cocaine or ethanol on C-shape movements over a 5-min exposure interval. ***P < 0.001 compared to lowest concentration of cocaine (0.1 mM) or ethanol (0.01%). N=8 planarians/group. 2B–C) Fixed concentrations of ETOH (0.01, 1%) were administered with increasing concentrations of cocaine (0,1, 0.5, 1, 2, 3, 4, 5 mM). C-shape movements were quantified over a 5-min exposure interval and data were presented as mean C-shapes + SEM versus log cocaine dose. N=8 planarians/group. A Student’s t-test comparing the expected and observed responses reveal synergy for the interaction (2B, P = 0.003 and 2C, P = 0.017).