Table 1.
MicroRNAs in skeletogenesis
| miRNA | Role in Differentiation | Expression in Embryonic Bone/Cartilage | Verified Targets | Citations |
|---|---|---|---|---|
| miR-140 | Unknown | Exclusively expressed in zebrafish, medaka, chicken, and mouse | HDAC4 | (22, 50, 52) |
| miR-140s | Unknown | Highly expressed in zebrafish | (22) | |
| miR-199a | Inhibits chondrocyte1 | Highly expressed in zebrafish, medaka, chicken, and mouse | (22, 50, 53) | |
| miR-199as | Inhibits chondrocyte1 | Highly expressed in zebrafish, medaka, chicken, and mouse | SMAD11 | (22, 50) |
| miR-26a | Inhibits osteoblast | SMAD1 | (57, 58) | |
| miR-126 | Unknown | VCAM1, HOXA9 | (61, 62) | |
| miR-125b | Inhibits osteoblast | ERBB2 | (64) | |
| miR-145 | Unknown | Highly expressed in zebrafish | (22) | |
| miR-146 | Unknown | Highly expressed in zebrafish | (22) |
VCAM1, vascular cell adhesion molecule 1; HOXA9, homeobox A9; ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
1
Lin and Liu, 2008, unpublished data