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Structure of PKC isozymes. PKCs are multidomain proteins that are regulated by lipids and protein-protein interactions. Diacyclycerol (DAG) generated upon activation of receptors causes the activation of cPKCs and nPKCs, and its actions are mimicked by phorbol esters. aPKCs do not respond to DAG or phorbol esters. PKCs activate a number of signal transduction pathways that regulate tumorigenesis and metastasis.
