Table 4.
Association of metabolites with childhood obesity–related cardiometabolic traits (r= correlation between a given pair of traits)
| Trait | BMI | WC | HDL | TRIG | SBP | DBP | HOMA |
|---|---|---|---|---|---|---|---|
| r (P-Value)a | r (P-Value)a | r (P-Value)a | r (P-Value)a | r (P-Value)a | r (P-Value)a | r (P-Value)a | |
| L-Thyronine | −0.471 (0.002) | −0.35 (0.023) | 0.39 (0.010) | −0.32 (0.036) | −0.31 (0.049) | −0.32 (0.041) | −0.17 (0.277) |
| Bradykinin | 0.565 (<0.001) | 0.53 (<0.001) | −0.51 (0.001) | 0.45 (0.003) | 0.31 (0.045) | 0.24 (0.124) | 0.29 (0.061) |
| Indole-3-propionic acid | −0.518(<0.001) | −0.46 (0.002) | 0.33 (0.035) | −0.09 (0.569) | −0.003 (0.984) | −0.03 (0.835) | 0.13 (0.399) |
| Naringenin | −0.652 (<0.001) | −0.62 (<0.001) | 0.34 (0.028) | −0.51 (0.001) | −0.31 (0.043) | −0.34 (0.030) | −0.42 (0.006) |
| 2-Methylbutyroylcarnitine | −0.177(0.2621) | −0.22 (0.168) | 0.11 (0.474) | −0.05 (0.754) | 0.09 (0.568) | 0.22 (0.157) | 0.15 (0.331) |
| 3-Hydroxyquinine | −0.510 (<0.001) | −0.59 (<0.001) | 0.39 (0.011) | −0.58 (<0.001) | 0.32 (0.041) | −0.23 (0.153) | −0.33 (0.034) |
| Vitamin D3b | −0.452 (0.003) | −0.44 (0.004) | 0.26 (0.102) | −0.48 (0.001) | −0.45 (0.003) | −0.44 (0.003) | −0.47 (0.002) |
| Lyso-PC | −0.403 (0.008) | −0.42 (0.006) | 0.24 (0.133) | −0.31 (0.049) | −0.17 (0.281) | −0.01 (0.977) | 0.11 (0.493) |
| Calicoferol B | −0.398 (0.009) | −0.50 (0.001) | 0.08 (0.628) | −0.29 (0.059) | −0.16 (0.300) | −0.09 (0.536) | −0.26 (0.102) |
| Diglyceride (DG) | −0.468 (002) | −0.36 (0.020) | 0.48 (0.001) | −0.41 (0.008) | −0.19 (0.231) | −0.24 (0.122) | 0.004 (0.979) |
| Malvidin3-(6-acetylglucoside) | −0.515 (<0.001) | −0.52 (<0.001) | 0.10 (0.545) | −0.36 (0.020) | −0.26 (0.092) | −0.27 (0.090) | −0.22 (0.159) |
| Linoleic acid | −0.529 (<0.001) | −0.52 (<0.001) | 0.13 (0.413) | −0.35 (0.024) | −0.31 (0.049) | −0.29 (0.0610 | −0.18 (0.252) |
| Phosphotidylethanolamine | 0.459 (0.002) | 0.45 (0.003) | −0.35 (0.021) | 0.64 (<0.001) | 0.48 (0.001) | 0.63 (<0.001) | 0.27 (0.079) |
| Phosphocholine (16:1) | 0.473 (0.002) | 0.47 (0.002) | −0.56 (<0.001) | 0.60 (<0.001) | 0.24 (0.122) | 0.44 (0.004) | 0.19 (0.237) |
a
Significant after accounting for multiple testing are shown in bold/italic and correlations with nominal significance are shown in bold;
b
1α,22-dihydroxy-23,24,25,26,27-pentanorvitamin D3 / 1α,22-dihydroxy-23,24,25,26,27-pentanorcholecalciferol.