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Differential innate immune response among CC lines in association with clinical outcome. Total RNA was isolated from spleens, brains, and kidneys from CC dRIX mice infected with WNV for the indicated times. Plots show qPCR results for IFN-β (A) and IFIT1 (B) expression in asymptomatic lines CC(041 × 012)F1 and CC(017 × 004)F1, symptomatic lines CC(005 × 001)F1 and CC(024 × 023)F1, and an asymptomatic line with CNS involvement, CC(004 × 011)F1.
