FIG 6 .
ARP2/3 chemical inhibition complements a legK2 gene deletion defect. (A) Actin polymerization on LCVs in the presence of CK-666. More than 100 LCVs were scored from each sample of phalloidin-FITC-labeled D. discoideum infected at an MOI of 100 with mCherry-labeled L. pneumophila Lens or the legK2 mutant in the absence or presence of 100 µM CK-666. These data are representative of three independent experiments, and the error bars represent the standard deviations. (B) Acquisition of vacuolar proton ATPase on LCVs in the presence of CK-666. More than 100 LCVs were scored for VatA immunolabeling in each sample of D. discoideum infected at an MOI of 100 with mCherry-labeled L. pneumophila Lens or the legK2 mutant in the absence or presence of 100 µM CK-666. These data are representative of three independent experiments, and the error bars represent the standard deviations. **, P < 0.01.