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HTS hits and Kd values as obtained from fluorescence polarization and IC50s of HTS hits obtained from luciferase assay dose-response curves
| HTS hit | Kd (µM) for Rgg3 | IC50 (nM)a |
|---|---|---|
| SHP2-C8 | 0.22 | |
| Cyclosporine A | 0.45 | 203.3 |
| Valspodar | 0.55 | 251.5 |
| Telmisartan | 8.3 | NT |
| Simvastatin | 9.7 | >10 µM |
| Saquinavir mesylate | 8.5 | >10 µM |
| Olmesartan | 19.8 | NT |
NT, not tested.
