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. Author manuscript; available in PMC: 2016 May 11.
Published in final edited form as: Integr Biol (Camb). 2015 Apr 30;7(5):591–609. doi: 10.1039/c4ib00295d

Figure 7.

Figure 7

Simulated antibiotic treatment of a representative granuloma. The granuloma is allowed to form for 100 days, after which treatment is initiated with daily doses of INH (15 mg/kg) and RIF (20 mg/kg) for an additional 180 days. These doses give plasma PK similar to that seen in humans[59]. (A) Average INH and RIF concentrations in the granuloma shown in panel C and the corresponding total bacterial load in the granuloma over time. C50 values (see Figure 6) for INH and RIF are indicated by dashed lines for each bacterial subpopulation (blue – INH; red – RIF). (B) Bacterial subpopulations in the granuloma over time during 180 days of treatment. (C) Snapshot of the granuloma on day 100, before treatment starts. (D) Cumulative exposure of the granuloma in panel C to RIF (top left) and INH (bottom right) over the first week of treatment, showing spatial distribution. Color bars are scaled between 0 and the EC80 (exposure where 80% of max efficiency is achieved) for each antibiotic.