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. 2015 May 15;12:94. doi: 10.1186/s12974-015-0311-y

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© Khan et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Experimental protocol. Schematic (A) shows the timeline of ATK treatment (7.5 mg/kg body weight) at 2 h after CEC begun day 0 and continued for 14 days. Pain was evaluated from days 1 to 5, and motor function was assessed from days 1 to 14 after CEC. Schematic (B) shows the location of placement of two silicone gel blocks implanted into the epidural spaces of L4 to L5 and L5 to L6 vertebrae, and schematic (C) shows the dimension of silicone gel block.