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. 2015 May 15;12:94. doi: 10.1186/s12974-015-0311-y

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© Khan et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of ATK on CEC-decreased threshold of pain. Pain threshold in animals was measured with AM (A) and DPA (B) for 5 days following CEC. Baseline represents the pain threshold of rats before CEC. CEC + VEH group was hyperalgesic when compared to respective ATK-treated group at least for 3 days following CEC. ATK treatment significantly decreased the hyperalgesia associated with CEC. Data are presented as mean ± SD (n = 8). **p < 0.01, ***p < 0.001 vs. CEC + VEH.