Table 2.
Meta-analysis results under the dominant genetic model
| SNP | Comparison | Gene symbol | No. | Q | Q-P | I 2 | Model | 95% CI | P |
|---|---|---|---|---|---|---|---|---|---|
| rs1048943 | GG + GA/AA | CYP1A1 A4889G | 8 | 8.8 | 0.12 | 0.43 | Fixed | 0.40[0.25,0.66] | 0.0002 |
| rs11134527 | AA + AG/GG | pri-miR-218 | 2 | 0 | 0.98 | 0 | Fixed | 1.25[1.06,1.47] | 0.007 |
| rs2279744 | TT + TG/GG | MDM2 | 2 | 3.32 | 0.07 | 0.7 | Fixed | 0.55[0.34,0.88] | 0.01 |
| rs4646903 | CC + CT/TT | CYPA1 T6235C | 8 | 33.12 | <0.0001 | 0.79 | Random | 1.65[1.12,2.43] | 0.01 |
| rs1801275 | AA + AG/GG | IL-4R | 2 | 0.15 | 0.69 | 0 | Fixed | 1.70[1.07,2.68] | 0.02 |
| rs1800872 | CC + AC/AA | IL-10 C592A | 5 | 1.88 | 0.76 | 0 | Fixed | 0.79[0.63,0.98] | 0.03 |
| rs62559044 | AA + AT/TT | IFN-r A874T | 4 | 2.47 | 0.48 | 0 | Fixed | 1.58[1.15,2.15] | 0.04 |
| rs1800896 | GG + GA/AA | IL-10 G1082A | 8 | 9.96 | 0.13 | 0.4 | Fixed | 1.19[0.99,1.44] | 0.06 |
| rs1800795 | GG + GC/CC | IL-6 | 3 | 4.46 | 0.11 | 0.55 | Fixed | 0.52[0.26,1.07] | 0.08 |
| rs1052134 | Ser326Cys | OGG1 | 2 | 1.42 | 0.23 | 0.29 | Fixed | 1.59[0.93,2.72] | 0.09 |
| rs352140 | GG + GA/AA | TLR9 G2848A | 3 | 4.81 | 0.09 | 0.58 | Fixed | 1.25[0.95,1.63] | 0.10 |
| rs3212227 | AA + AC/CC | IL-12B | 2 | 2.03 | 0.15 | 0.51 | Fixed | 0.77[0.56,1.06] | 0.11 |
| rs833061 | TT + TC/CC | VEGF T460C | 2 | 1.33 | 0.25 | 0.25 | Fixed | 1.75[0.85,3.59] | 0.13 |
| rs1805087 | AA + AG/GG | MTR A2756G | 2 | 2.72 | 0.1 | 0.63 | Fixed | 1.64[0.83,3.27] | 0.16 |
| rs1801133 | TT + TC/CC | MTHFRC677T | 8 | 28.67 | 0.0002 | 0.76 | Random | 0.81[0.60,1.10] | 0.17 |
| rs5742909 | TT + TC/CC | CTLA-318 | 5 | 19.13 | 0.0007 | 0.79 | Random | 1.43[0.86,2.39] | 0.17 |
| rs1800629 | GG + GA/AA | TNF-α-308 | 15 | 52.19 | <0.00001 | 0.75 | Random | 0.82[0.57,1.18] | 0.28 |
| rs187084 | TT + TC/CC | TLR9T1486C | 3 | 2.4 | 0.3 | 0.17 | Fixed | 0.88[0.71,1.11] | 0.29 |
| rs16944 | CC + CT/TT | IL-1β | 4 | 16.3 | 0.001 | 0.82 | Random | 0.76[0.45,1.28] | 0.30 |
| rs568408 | GG + GA/AA | IL-12A | 2 | 0.64 | 0.42 | 0 | Fixed | 0.79[0.46,1.35] | 0.39 |
| rs1800682 | GG + GA/AA | Fas | 9 | 63.31 | <0.00001 | 0.87 | Random | 1.20[0.77,1.87] | 0.41 |
| rs763110 | TT + TC/CC | FASL T844C | 2 | 13.18 | 0.0003 | 0.92 | Random | 0.77[0.38,1.52] | 0.45 |
| rsl801270 | CC + CA/AA | p21 codon 31 | 7 | 31.99 | <0.0001 | 0.81 | Random | 0.83[0.51,1.35] | 0.46 |
| rs1799864 | AA + GA/GG | CCR2 | 3 | 128 | <0.0001 | 0.98 | Random | 1.65[0.35,7.82] | 0.52 |
| rs361525 | GG + GA/AA | TNF-α-238 | 8 | 399 | <0.0001 | 0.98 | Random | 1.98[0.24,16.2] | 0.53 |
| rs3116496 | CC + CT/TT | CD28 | 3 | 17.6 | 0.0002 | 0.89 | Random | 1.14[0.69,1.88] | 0.61 |
| rs3021097 | CC + CT/TT | IL-10 C819T | 2 | 1.27 | 0.26 | 0.21 | Fixed | 1.05[0.73,1.49] | 0.80 |
| rs603965 | GG + GA/AA | CCND1 | 6 | 4.24 | 0.52 | 0 | Fixed | 0.98[0.82,1.17] | 0.80 |
| rs1801131 | AA + CA/CC | MTHFR A1298C | 2 | 2.95 | 0.09 | 0.66 | Fixed | 1.07[0.63,1.81] | 0.81 |
| rs3025039 | CC + CT/TT | VEGF C936T | 2 | 2.28 | 0.13 | 0.56 | Fixed | 1.08[0.57,2.04] | 0.82 |
| rs5275 | CC + CT/TT | COX-2 | 2 | 0.03 | 0.86 | 0 | Fixed | 0.98[0.73,1.32] | 0.91 |
| rs4404252 | TT + TC/CC | ICOS T/C | 2 | 0.02 | 0.88 | 0 | Fixed | 0.99[0.64,1.54] | 0.98 |
No, number of studies; OR, combined odds ratio; CI, confidence interval; P, P value.