Table 4.
Gene symbol | Comparison | No. | Q | Q-P | I 2 | Model | 95% CI | P |
---|---|---|---|---|---|---|---|---|
GSTM1 | postive/null | 16 | 60.49 | <0.00001 | 0.75 | Random | 0.70[0.53,0.92] | 0.01 |
GSTT1 | postive/null | 15 | 69.88 | <0.00001 | 0.8 | Random | 0.69[0.60,0.97] | 0.03 |
G4C14-to-A4T14 P73 | GG/GA + AA | 2 | 0.61 | 0.44 | 0 | Fixed | 0.74[0.55,1.00] | 0.05 |
P53 codon 72 | C/G | 44 | 268 | <0.00001 | 0.84 | Random | 1.14[0.99,1.34] | 0.07 |
P53 codon 72 | CC/CG + GG | 44 | 242.19 | <0.00001 | 0.83 | Random | 1.18[0.96,1.42] | 0.11 |
XRCC3 Codon 241 | CC/CT + TT | 5 | 6.35 | 0.17 | 0.37 | Fixed | 0.82[0.63,1.06] | 0.14 |
G4C14-to-A4T14 P73 | G/A | 2 | 0.1 | 0.76 | 0 | Fixed | 0.83[0.65,1.07] | 0.16 |
GSTP1 | AA/AG + GG | 2 | 0.97 | 0.61 | 0 | Fixed | 0.88[0.69,1.11] | 0.28 |
XRCC1 Codon 194 | CC/CT + TT | 9 | 17.78 | 0.02 | 0.55 | Fixed | 0.92[0.79,1.08] | 0.32 |
XRCC1 Codon399 | GG/GA + AA | 12 | 61.12 | <0.0001 | 0.82 | Random | 1.18[0.84,1.64] | 0.33 |
XRCC1 Codon399 | G/A | 12 | 203.12 | <0.00001 | 0.95 | Random | 1.23[0.80,1.91] | 0.34 |
XRCC1 Codon194 | CC + CT/TT | 9 | 21.11 | 0.007 | 0.62 | Random | 0.78[0.41,1.46] | 0.44 |
GSTP1 | A/G | 2 | 0.03 | 0.86 | 0 | Fixed | 0.93[0.76,1.14] | 0.48 |
G4C14-to-A4T14 P73 | GG + GA/AA | 2 | 0.89 | 0.34 | 0 | Fixed | 1.23[0.60,2.52] | 0.56 |
P53 codon 72 | CC + CG/GG | 44 | 99.69 | <0.0001 | 0.59 | Random | 1.06[0.90,1.23] | 0.57 |
XRCC1 Codon399 | GG + GA/AA | 11 | 171.77 | <0.0001 | 0.94 | Random | 1.22[0.49,3.01] | 0.67 |
GSTP1 | AA + AG/GG | 2 | 0.1 | 0.76 | 0 | Fixed | 0.93[0.51,1.69] | 0.80 |
XRCC3 Codon241 | CC + CT/TT | 5 | 13.95 | 0.003 | 0.78 | Random | 0.88[0.27,2.85] | 0.83 |
XRCC1 Codon194 | C/T | 9 | 25.69 | <0.00001 | 0.69 | Random | 0.99[0.73,1.33] | 0.93 |
No, number of studies; OR, combined odds ratio; CI, confidence interval; P, P value.