Table 1. Effects of short-term intermittent hypoxia (IH) and high-fat diet (HFD) on body weight, food intake, liver mass, epididymal fat pad, lipid metabolism, and liver triglyceride content in mice.
| IA-SD | IH-SD | IA-HFD | IH-HFD | |
|---|---|---|---|---|
| N | 24 | 24 | 24 | 24 |
| Daily food intake | ||||
| g | 3.3±0.8 | 3.4±0.9 | 3.1±0.8 | 2.5±0.6 # * |
| kcal | 10.9±2.6 | 11.2±3.0 | 13.9±3.6* | 11.2 ±2.7 # |
| Weight gain, g | 2.9±1.8 | 2.1±1.4 | 4.3±1.0* § | 2.0±1.3 # |
| Liver weight, g | 1.2±0.1 | 1.2±0.2 | 1.3±0.2 | 1.1±0.1 |
| Liver weight/body weight, % | 4.7±0.2 | 4.7±0.5 | 4.5±0.5 | 4.3±0.4 |
| Epididymal fat weight, g | 0.4±0.2 | 0.4±0.2 | 0.6±0.2* § | 0.6±0.2* § |
| Epididymal fat weight/body weight, % | 1.5±0,2 | 1.5±0.3 | 2.3±0.7* § | 2.1±0.7* § |
| Fasting serum cholesterol, g/L | 0.95±0.12 | 0.98±0.15 | 1.4±0.15* § | 1.4±0.16* § |
| Fasting serum triglycerides g/L | 0.61±0.14 | 0.63±0.15 | 0.60±0.17 | 0.59±0.11 |
| Liver triglycerides mg/g | 192±60 | 218±60 | 302±49* | 218±245 # |
Values are expressed as mean ± standard deviation;
*p<0.05 vs IA-SD.
# p<0.05 vs IA-HFD mice.
§ p<0.05 vs IH-SD. IA intermittent air, IH intermittent hypoxia, SD standard diet, HFD high fat diet