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. 2015 May 18;10(5):e0126856. doi: 10.1371/journal.pone.0126856

Fig 5. Light Microscopic Analysis of Hippocampal CA1.

Fig 5

Photomicrographs of toluidine blue-stained hippocampal CA1 neurons in a normal control rat (A) and rats that received an injection of PBS (B), 0.2 mg/kg PS18 (C), or 2.0 mg/kg PS18 after a KA injection (D). Injured CA1 neurons were rescued by a PS18 treatment (C, D). Note that many injured neurons lined the apical side of the pyramidal layer. Scale bar = 100 μm. Effects of PS18 on injured (E) and viable (F) neurons in the hippocampal CA1 region in rats that received a subcutaneous injection of 12 mg/kg KA. PS18 treatment administered to KA-injected rats decreased the number of injured neurons (E) and increased the number of viable neurons (F) in a dose-dependent manner compared with the PBS-treated KA-injected rats. **P < 0.01. A P-value < 0.05 was considered to be statistically significant. All data are expressed as mean ± standard error of the mean (S.E.M.).