Table 3. Adjusted associations between breastfeeding and memory B- and T-cell subsets at 6 months.
| Regression coefficients for logtransformed cell numbers (*10e9/L) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B (n = 258) | T CD4 + (n = 258) | T CD8+ (n = 258) | ||||||||||||
| Naive B CD27- IgD+ | CD27+IgM+ | CD27+IgA+ | CD27-IgA+ | CD27+IgG+ | CD27-IgG+ | CD4+ T naive | CD4+T cm | CD4+TemRO | CD4+TemRA | CD8+T naive | CD8+T cm | CD8+TemRO | CD8+TemRA | |
| DURATION | ||||||||||||||
| Breastfeeding (n = 223) increase per month | -1(-3,1) | -3(-6,-1) * | -2 (-5,-1) * | -2 (-5,1) | 1 (-3,2) | -2 (-4,-1) * | -2 (-3,0) | -1(-2,1) | -1(-3,2) | 0(-3,2) | -2 (-4,1) | 0(-2,3) | 0(-3,3) | 2 (-1,5) |
| EXPOSURE | ||||||||||||||
| Never (n = 35) | REF | REF | REF | REF | REF | REF | REF | REF | REF | REF | REF | REF | REF | REF |
| < 3 months (n = 86) | 12 (-6,31) | 9(-19,36) | 1 (-28,30) | 15 (-14,43) | -9 (-34,16) | -1 (-22,22) | 7(-10,24) | -3(-20,14) | 17(-4,38) | 14(-8,37) | 23 (0,46) | 30 (4,57) * | 15(-18,47) | 20(-8,47) |
| ≥ 3 < 6 months (n = 64) | 18 (-1,38) | 18(-11,48) | 1 (-30,32) | 14 (-17,44) | 0 (-26,27) | 1 (-22,25) | 4(-14,22) | -5(-23,13) | 9(-14,31) | 8(-16,32) | 23 (-2,448) | 17 (-11,45) | -4(-38,31) | 9 (-20,39) |
| ≥ 6 months (n = 73) | 6 (-13,26) | -4(-34,25) | -11 (-40,19) | -2 (-31,28) | -7 (-33,19) | -13 (-36,10) | -5(-23,14) | -3(-21,15) | 13(-10,35) | 10(-14,34) | 10(-15,34) | 29 (1,57) * | -5(-39,30) | 21(-9,51) |
Values are log transformed regression coefficients (95% confidence interval of cell numbers (*10e9/L)) derived from linear regression models and reflect the increase or decrease (%) in log transformed cell numbers per month continuation of breastfeeding.(duration), and the increase or decrease (%) in log transformed cell numbers of groups exposed to breastfeeding relative to the reference group (never breastfeeding). Breastfed groups include both partially and exclusively breastfed children.
*P-value <0.05. Adjusted for maternal education and maternal alcohol use during pregnancy.