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Effects of curcumin pretreatment on PTEN/Akt/p53 and HO-1 signaling proteins expression. (a) Representative Western blots of PTEN, p-Akt, Akt, p53, HO-1, cleave-caspase-3, caspase-3, and β-actin. ((b)–(f)) Quantitative analysis of PTEN, p-Akt, Akt, p53, HO-1, and cleave-caspase-3. The results showed that curcumin pretreatment significantly increased the expression of p-Akt and HO-1 and reduced the PTEN, p53, and cleave-caspase-3 expression (P < 0.05). ∗ P < 0.05.
