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. 2015 May 5;2015:638153. doi: 10.1155/2015/638153

Figure 5.

Figure 5

Administration of pretreated ADSCs increases cells retention and decreases myocardial fibrosis and apoptosis after myocardial infarction at 7 days after transplantation. (a) Representative fluorescence microscopic images ADSCs (Dil+, red florescence), cardiomyocytes (cTnI, green florescence), and DAPI (blue fluorescence) at 1 week after injection. Quantitative analysis revealed that a higher retention of ADSCs in Cur-ADSCs group was observed. Scale bars = 50 μm. ∗ P < 0.05 versus ADSCs. (b) Effect of ADSCs transplantation and/or pretreatment with curcumin on infarct size. Representative TTC staining images and quantitative analysis at 7 days after transplantation showed intramyocardial injection of ADSCs decreased the LV infarct size (P < 0.05). Scale bars = 100 μm. Statistical differences (P < 0.05) are indicated from PBS (∗) and ADSCs (#). (c) Measurement of apoptosis in the ischemic heart. Representative TUNEL staining images in the peri-infarct area of heart slices by immunofluorescence and quantitative analysis showed TUNEL positive cells were the least in the Cur-ADSCs group (P < 0.05). Scale bars = 100 μm. Statistical differences (P < 0.05) are indicated from PBS (∗) and ADSCs (#).