Table 3.

Promoter motif signatures from Table 2 compared to chemical and genetic perturbation gene sets in c2.cgp.v4.0.symbols.gmt. The identified chemical or genetic perturbation is shown experimentally to down regulate the enriched genes in the Genes found column.

Chemical or genetic perturbations	CGP gene set	Genes found
Ras inhibitor Salirasib	BLUM_RESPONSE_TO_SALIRASIB_DN	V$E2F_01 = [DNMT1 MCM3 NASP RANBP1 SMC4] V$E2F_Q3 = [CDC25A CDC45 CDK1 DNMT1 EZH2 FBXO5 GMNN KIF15 MCM3 MCM6 NASP PLK4 POLA2 RANBP1 USP1] KTGGYRSGAA_UNKNOWN = [EZH2 MCM3 MCM6 POLD1 RANBP1 RFC4 SYNCRIP]
EGFR inhibitor CL-387785	KOBAYASHI_EGFR_SIGNALING_24HR_DN	V$E2F_Q3 = [CDC25A CDC45 CDK1 EZH2 GMNN KIF15 MCM3 MCM4 MCM6 MCM7 PLK4 POLA2 RANBP1 TIPIN USP1]
Aminopeptidase inhibitor Tosedostat (CHR-2797)	KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN	V$E2F_01 = [AMD1 MYC NASP RANBP1 SMC4]
SB216763 inhibitor of GSK3B	WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN	V$E2F_01 = [MCM3 MCM4 MYC NASP RANBP1] KTGGYRSGAA_UNKNOWN = [MCM3 MCM6 MCM7 MYC PIM1 RANBP1 TUBA4A]
Knockout TLX	ZHANG_TLX_TARGETS_60HR_DN	V$E2F_01 = [AMD1 DNMT1 MCM3 MCM4 NASP SMC4] KTGGYRSGAA_UNKNOWN = [EZH2 MCM3 MCM6 MCM7 POLD1 RFC4 SYNCRIP]
Knockout BMP2	LEE_BMP2_TARGETS_DN	V$E2F_Q3 = [CDC25A CDC45 DNMT1 E2F3 EZH2 GMNN KLF5 MCM3 MCM4 MCM6 MCM7 NASP NUP153 PLK4 RANBP1 TIPIN USP1] V$E2F_01 = [AMD1 DNMT1 E2F3 MCM3 MCM4 NASP RANBP1]