Table 2.
The genotype and allele frequencies of IL-6 (- 174 G/C and - 572 G/C) gene polymorphisms.
| Controls | OSCC n = 272 (%) | p- Value | OR (95% CI) | OSCC with cancer stages I & II | p- Value | OR (95% CI) | OSCC with cancer stages III & IV | p- Value | OR (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|---|
| IL-6 (174) | ||||||||||
| GG | 129 (69.73) | 150 (55.15) | - | - | 96 (54.86) | - | - | 54 (55.67) | - | - |
| GC | 47 (25.41) | 101 (37.13) | 0.005⁎ | 1.848 (1.216-2.809) |
66 (37.72) | 0.009⁎ | 1.887 (1.194-2.983) |
35 (36.08) | 0.05⁎ | 1.779 (1.036-3.055) |
| CC | 9 (4.86) | 21 (7.72) | 0.132 | 2.007 (0.888-4.537) |
13 (7.42) | 0.2092 | 1.941 (0.797-4.728) |
8 (8.25) | 0.222 | 2.123 (0.778-5.796) |
| Allele | ||||||||||
| G | 305 (82.43) | 401 (73.71) | - | - | 258 (73.72) | - | - | 143 (73.72) | - | - |
| C | 65 (17.57) | 143 (26.29) | 0.003⁎ | 1.673 (1.204-2.325) |
92 (26.28) | 0.006⁎ | 1.673 (1.169-2.394) |
51 (26.28) | 0.0201⁎ | 1.673 (1.103-2.540) |
| IL-6 (-572) | ||||||||||
| GG | 57 (30.81) | 75 (27.57) | - | - | 44 (25.14) | - | - | 31 (31.95) | - | - |
| GC | 115 (62.16) | 175 (64.34) | 0.564 | 1.157 (0.762-1.755) |
115 (65.72) | 0.337 | 1.295 (0.809-2.074) |
60 (61.87) | 0.988 | 0.959 (0.561-1.642) |
| CC | 13 (7.03) | 22 (8.09) | 0.6519 | 1.286 (0.597-2.771) |
16 (9.14) | 0.371 | 1.594 (0.695-3.660) |
6 (6.18) | 0.970 | 0.849 (0.294-2.454) |
| Allele | ||||||||||
| G | 219 (59.29) | 325 (59.74) | - | - | 203 (58.00) | - | - | 121 (62.37) | - | - |
| C | 141 (40.71) | 219 (40.26) | 0.796 | 1.047 (0.797-1.374) |
147 (42.00) | 0.489 | 1.125 (0.833-1.518) |
72 (37.63) | 0.736 | 0.924 (0.645-1.325) |
⁎
= Significant value