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. 2015 Jun;21(6):1187–1202. doi: 10.1261/rna.049890.115

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© 2015 Tejedor et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 2. — Additional nucleotide identities in the allelic series attenuate the effect of SNP rs3736234 on OLR1 AS. (A) Nucleotide-specific effect of rs3736234 and rs13306593 SNP substitutions. The scheme indicates the individual substitutions from Low- to High-Risk allelic series and from Low to a different nucleotide. Data represent mean and standard deviation of exon 5 inclusion/skipping ratios of the different constructs after normalization to Low-Risk minigenes for six independent biological replicas. Significant P-values obtained from Student's two-tailed heteroscedastic t-test are indicated: (*) <0.05, (**) <0.01. (B) The table indicates the accumulative series mutations introduced in the Low-Risk minigene to reconstruct the genotype of the High-Risk allele series (in bold). (C) Ratio of exon 5 inclusion/skipping for the constructs indicated in B, normalized to the values of the Low-Risk minigene. Values represent mean and standard deviation for eight independent biological replicas. P-values for each of the conditions are indicated.