Fig. 4.

Mutations in low-frequency genes can affect cell growth. a HOG cells stably expressing wildtype GDI1 show increased proliferation compared to GDI1 ^R193C expressing cells (p = 0.003, n = 2 independent experiments). b Cells stably expressing XPO7 ^D237N show a higher rate of proliferation during the first 24 h, compared to wildtype expressing cells (p = 0.02, (n = 2)). After 24 h, similar proliferation rates were observed in wildtype and XPO7 ^D237N. c HOG cells stably expressing SASH3 wildtype or SASH3 ^R288* and d wildtype or ZNF238 ^V121I show similar proliferation rates (n = 3)