. Author manuscript; available in PMC: 2015 May 19.

Published in final edited form as: Neurotoxicol Teratol. 2009 Sep 30;32(2):132–141. doi: 10.1016/j.ntt.2009.09.005

Table 2.

Neurobehavioral Effects of Developmental Exposure to Domoic Acid

IP Treatment Effects (mg/kg) (Rodent data) Doses
0.05	0.1	0.2		2
Hyperactivity	Scratching	Scratching Seizures		Death
IV Treatment Effects (mg/kg) (Rodent data)
0.6
EEG abnormalities
Subcutaneous Treatment Effects (mg/kg) (Rodent data)
0.05	0.1	0.33	0.5	1.2
Lethargy	Death	Paralysis Tremor Death	Paralysis Tremor Death	Changes in cognition and motor behavior
Subcutaneous Treatment (μg/kg) (Rodent data)
20
Facilitative effects on early CNS development and adult learning Memory impairment Emotionality Hyperreactivity Behavioral seizures