Table 1.
Genotype frequencies and odds ratios for UC and CD of PTGS2 SNPs
| Genotype |
Controls |
UC |
CD |
|||||
| n1 | % | n1 | % | OR(95%CI)2 | n1 | % | OR(95%CI)2 | |
| PTGS2.401 | ||||||||
| A/A | 277 | 79 | 115 | 82 | 1 | 107 | 77 | 1.00 |
| A/G | 66 | 19 | 24 | 17 | 0.82 (0.48 – 1.39)3 | 30 | 22 | 1.17 (0.70 –1.94)3 |
| G/G | 7 | 2 | 1 | 1 | 1 | 1 | ||
| Total | 350 | 100 | 140 | 100 | 138 | 100 | ||
| PTGS2.926 | ||||||||
| G/G | 256 | 75 | 112 | 81 | 1 | 106 | 76 | 1.00 |
| G/C | 75 | 22 | 23 | 17 | 0.77 (0.47 – 1.28)3 | 31 | 22 | 1.06 (0.65 –1.73)3 |
| C/C | 8 | 2 | 4 | 3 | 3 | 2 | ||
| Total | 339 | 100 | 139 | 100 | 140 | 100 | ||
| PTGS2.3050 | ||||||||
| G/G | 250 | 71 | 109 | 75 | 1 | 102 | 71 | 1 |
| G/C | 99 | 28 | 32 | 22 | 0.83 (0.52 – 1.32)3 | 38 | 26 | 0.97 (0.62 –1.53)3 |
| C/C | 1 | 1 | 4 | 3 | 4 | 3 | ||
| Total | 350 | 100 | 145 | 100 | 144 | 100 | ||
| PTGS2.5209 | ||||||||
| T/T | 265 | 75 | 110 | 76 | 1 | 95 | 66 | 1 |
| T/G | 81 | 23 | 30 | 21 | 1.00 (0.62 - 1.61)3 | 46 | 33 | 1.63 (1.03 - 2.57)3 |
| G/G | 7 | 2 | 5 | 3 | 2 | 1 | ||
| Total | 353 | 100 | 145 | 100 | 143 | 100 | ||
| PTGS2.8473 | ||||||||
| C/C | 44 | 13 | 18 | 14 | 1.003 | 21 | 15 | 1.003 |
| T/C | 147 | 42 | 49 | 34 | 54 | 38 | ||
| T/T | 155 | 45 | 78 | 54 | 1.50 (1.00 - 2.27) | 68 | 47 | 1.10 (0.72 - 1.68) |
| Total | 346 | 100 | 145 | 100 | 143 | 100 | ||
1Numbers may not sum up to the totals of controls or cases due to genotyping failure. All samples that did not give a reliable result in the first round of genotyping were resubmitted to up to three additional rounds of genotyping. Data points that were still not filled after this procedure were left blank.
2
All ORs are adjusted for sex and age.
3
Heterozygotes and homozygotes for the rare allele have been grouped in order to improve statistical power