Table 2.
PTGS2 haplotype frequencies and odds ratios for IBD
| Haplotype1 | Controls |
UC cases |
CD cases |
UC+CD cases2 |
|||
| n (%) | n (%) | OR(95% CI) | n (%) | OR (95% CI) | n (%) | OR (95% CI)3 | |
| AGTT | 471 (64.7) | 193 (65.6) | 1.00 (Ref.) | 183 (62.7) | 1.00 (Ref.) | 376 (64.2) | 1.00 (Ref.) |
| AGTC | 147 (20.2) | 55 (18.7) | 0.91 (0.64 - 1.30) | 54 (18.5) | 0.95 (0.66 - 1.35) | 109 (18.6) | 0.93 (0.69 - 1.24) |
| GCGC | 64 (8.8) | 22 (7.5) | 0.84 (0.50 - 1.39) | 27 (9.2) | 1.09 (0.67 - 1.75) | 49 (8.4) | 0.96 (0.63 - 1.45) |
| ACGC | 25 (3.4) | 8 (2.7) | 0.78 (0.35 - 1.73) | 7 (2.4) | 0.72 (0.31 - 1.66) | 15 (2.6) | 0.75 (0.36 - 1.51) |
| AGGT | 2 (0.3) | 10 (3.4) | 12.2 (2.97 – inf.) | 9 (3.1) | 11.58 (2.79 -inf.) | 19 (3.2) | 11.9 (2.83 – 105.76) |
| Rare4 | 19 (2.6) | 6 (2.0) | 0.77 (0.31 - 1.90) | 12 (4.1) | 1.63 (0.78 - 3.37) | 18 (3.1) | 1.19 (0.61 – 2.29) |
1
The order of SNPs in the haplotypes is PTGS2.401, PTGS2.926, PTGS2.5209, PTGS2.8473 .
2
UC and CD combined.
3
ORs are not corrected, they are based on population level haplotype frequencies and are relative to the most common haplotype (AGTT).
4
Rare haplotypes (frequency ≤1% in both cases and controls)