TABLE 1:
Proteins with dileucine-based basolateral sorting signals.
| Protein | BL signal and key residues | Endocytic activity | BL sorting machinery | Reference |
|---|---|---|---|---|
| ClC-2 | TIFSLL | ? | AP-1B | Peña-Münzenmayer et al. (2005) |
| ClC-2 | ESMILL | ? | AP-1A, AP-1B | This study |
| IgG Fc receptor B-cell 1 (FcRII-B1) | ITYSLL | Yes | ? | Hunziker and Fumey (1994) |
| Neonatal IgG-Fc receptor (FcRn) | DSGDLL | Yes | ? | Newton et al. (2005) |
| Glycine transporter 1b (GLYT 1b) | DGDTLL | ? | ? | Poyatos et al. (2000) |
| Lutheran antigen(Lu) | EQTGLL | ? | ? | Nemer et al. (1999) |
| Melanoma cell adhesion molecule isoform 1 (MCam-1) | EEAGLL | ? | ? | Guezguez et al. (2006) |
| Cu2+-translocating ATPase (ATP7A) | DKHSLL | ? | ? | Greenough et al. (2004) |
| MHC class II invariant chain (MHC-Ii) | DQRDLL | ? | ? | Simonsen et al. (1997) |
| EQLPML | ? | |||
| E-cadherin | VKEPLL | ? | PIPK-1γAP-1B | Miranda et al. (2001) Ling et al. (2007) |
| IgG Fc receptor B-cell 1 (FcRII-B1) | ITYSLL | Yes | ? | Hunziker and Fumey (1994) |
| Glycoprotein 130 (GP130) | STQTLL | Yes | ? | Doumanov et al. (2006) |
| Ectonucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) | AAASLL | Yes | ? | Bello et al. (2001) |
| Rat sulfate anion transporter 1 (SAT-1) | TAEELL | Yes | ? | Regeer and Markovich (2004) |
IgG, immunoglobulin G.
National Center for Biotechnology Information sequences of [D/E]XXXL[L/I] dileucine motifs in the cytoplasmic domain of indicated transmembrane cargo proteins. Critical residues for basolateral sorting are highlighted in bold.