Figure 8. LPCAT3-deficient mice are neonatally lethal.
(A–D) The survival rate (A), gross appearance (B and C), and body weight change (n = 9–62) (D) were evaluated in neonatal mice of the indicated genotypes. Arrowhead: normal milk intake in both genotypes. (E and F) Blood glucose was measured in wild type and LPCAT3-deficient mice at P0.5 (E) and P1.5 (F). Error bars are SEM. *p < 0.05, **p < 0.01. See also Figure 8—figure supplement 1.
Figure 8—figure supplement 1. Plasma insulin and liver glycogen in LPCAT3-deficient mice.
(A–D) Plasma insulin (A and B) and liver glycogen (C and D) were measured in wild type and LPCAT3-deficient mice at P0.5 and P1.5. Notice that insulin is not higher in LPCAT3-deficient mice than in wild type mice, and that liver glycogen levels are reduced at P1.5 in both genotypes.