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. 2015 May 19;9:175. doi: 10.3389/fnins.2015.00175

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Copyright © 2015 Paluzzi, Bhatt, Wang, Zandawala, Lange and Orchard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The serotonin type 2 receptor agonist, α–methyl serotonin, is a weak cardioactive factor in R. prolixus. (A) Sample traces of 100 nM serotonin and selected concentrations of α–methyl serotonin. Black bars denotes application of serotonin or agonist at specified dose to preparations displaying spontaneous heart beats in saline. (B) Bar graph summary of the frequency of heart contractions (beats/min) under saline, serotonin or various concentrations of α–methyl serotonin. Columns marked with different letters are significantly different (ANOVA, Tukey-Kramer multiple comparison test, P < 0.05). Data points are means ± standard error (n = 8 for each data point).