Fig. 4. Reconstructed metabolic network for systematic screening of therapeutic target point. The re-modeled metabolic structure is composed of metabolites, which consists of node (e.g. metabolite) and edge (e.g. correlation, structural similarity). The model may be extended to protein information via reaction pair that has already been built in the assembly, which could unravel “hidden” or veiled metabolic modulation, particularly in chronic disease. In this example, node color and size indicate significant difference and fold change compared to control (e.g. disease vs control), while edge presents two layers of information on structural similarity and reaction likelihood, which leads to automatic rearrangement as seen in the figure indicating proximity of biochemical module.