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. 2015 May 19;7:84. doi: 10.3389/fnagi.2015.00084

FIGURE 7.

FIGURE 7

Proteins related to CMA and homeostasis are differentially affected in AD and CI. Representative bands from SS-Cx lysates of 3xTgAD and ischemic rats were evaluated by Western blotting (A) CHIP was unmodified, (B) Hsc70 decreased at 12 months (p ≤ 0.302) and at 18 months (p ≤ 0.034), (C) Hsp90 increased at 6 months (p ≤ 0.0409), (D) LAMP-2 levels were unaltered in the 3xTg-AD mice. (E) CHIP was unmodified, (F) Hsc70 and (H) LAMP2 increased at the intermediate stage (15 days) post-stroke (p ≤ 0.05). (G) Hsp90 levels increased at 1 (p ≤ 0.0432) and 15 days (p ≤ 0.0093) and decreased at 30 days (p ≤ 0.0076) after ischemia. The data were normalized against the internal control for each time point in the NoTg mice and sham rats, respectively. β-III tubulin and actin were used as the loading controls. The data are shown in the bar graph as AUs. The data were compared to the internal control values for each time point in the disease progression. The data are presented as the mean ± SEM; n = 3–5; ∗p < 0.05; ∗∗p < 0.001.