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. 2015 May 7;114(6):979–989. doi: 10.1093/bja/aev095

Fig 3.

Fig 3

Effect of ketamine on coherence and power spectral density (PSD). (a) Representative coherogram showing a significant decrease in coherence during ketamine-induced unconsciousness (Ketamine) and the appearance of high-frequency gamma coherence during emergence and after the return of righting reflex (RORR). (b) Statistical comparisons (repeated measures anova) of changes in coherence between Wake (blue), Ketamine-induced unconsciousness (gold), Pre-RORR (Pink), and Post-RORR (green; n=8 animals). The fifth bar (orange) represents the Recovery epoch from the rats with extended recovery and was compared (one-tailed Wilcoxon text) with the Wake state from the same rats. (c) Representative spectrogram showing a significant decrease in power in higher gamma frequencies during ketamine-induced unconsciousness (Ketamine) and the appearance of high-frequency gamma power during emergence and after RORR. (d) Statistical comparisons (repeated measures anova) of changes in PSD between Wake (blue), Ketamine-induced unconsciousness (gold), Pre-RORR (Pink), and Post-RORR (green; n=8 animals). The fifth bar (orange) represents the Recovery epoch from the rats with extended recovery and was compared (one-tailed Wilcoxon text) with the Wake state from the same rats. The right axis applies only to the grey shaded area. *P<0.05 significant compared with Wake; #P<0.05 significant compared with Ketamine. Most of the comparisons are highly significant, but in order to avoid crowding the figure with the significance symbols, all the significance values are reported as P<0.05. The accurate P-values are reported in the text in the Results section.