Table 1.
Nitric oxide in immune cells
| Cell compartment | Features | Ref. |
| Innate immunity | ||
| Macrophage | ||
| M1 | High level of NO | [55-59,61] |
| Expression of iNOS | ||
| NO-mediated cytotoxicity | ||
| M2 | Reduced level of NO | |
| Immune suppressive function | ||
| Natural Killer cells | ||
| NO-mediated cytotoxicity | [84,85] | |
| NO-mediated cell fitness | ||
| Mast cells | ||
| NOS expression | [87,89-91,93] | |
| NO-mediated cell adhesion and function | ||
| Myeloid-derived suppressor cell | ||
| iNOS expression | [62,64,94,95] | |
| Immune modulating function | ||
| Dendritic cells | ||
| NOS expression | [72,73,75-77] | |
| Pathogen clearance | ||
| Adaptive immunity | ||
| Lymphocyte | ||
| T-cell | T-cell activation and function | [64-68,72,73] |
| T-cell commitment | ||
| B-cell | Reduced level of NO | [69] |
| T-independent antibody response | ||
NO: Nitric oxide; NOS: Nitric oxide synthase; iNOS: Inducible NOS.