Table 1.
Cell compartment | Features | Ref. |
Innate immunity | ||
Macrophage | ||
M1 | High level of NO | [55-59,61] |
Expression of iNOS | ||
NO-mediated cytotoxicity | ||
M2 | Reduced level of NO | |
Immune suppressive function | ||
Natural Killer cells | ||
NO-mediated cytotoxicity | [84,85] | |
NO-mediated cell fitness | ||
Mast cells | ||
NOS expression | [87,89-91,93] | |
NO-mediated cell adhesion and function | ||
Myeloid-derived suppressor cell | ||
iNOS expression | [62,64,94,95] | |
Immune modulating function | ||
Dendritic cells | ||
NOS expression | [72,73,75-77] | |
Pathogen clearance | ||
Adaptive immunity | ||
Lymphocyte | ||
T-cell | T-cell activation and function | [64-68,72,73] |
T-cell commitment | ||
B-cell | Reduced level of NO | [69] |
T-independent antibody response |
NO: Nitric oxide; NOS: Nitric oxide synthase; iNOS: Inducible NOS.