Table 3. Relationship between clinical and laboratory CF variables and H/A index using generalized linear models with GEE (Generalized Estimating Equations).

Variables	Estimate	Standard error	95%CI		p value
Pseudomonas aeruginosa
No	0.203	0.123	—0.038	0.444	0.099
Yes	0	0	0	0	—
Pancreatic Insufficiency
No	0.169	0.137	—0.099	—0.437	0.217
Yes	0	0	0	0	—
Hepatopathy
No	0.066	—0.123	—0.176	—0.308	0.593
Yes	0	0	0	0	—
Spirometry
FVC (%)	—0.001	0.003	—0.007	0.005	0.788
FEV1 (%)	—0.001	0.004	—0.009	0.006	0.749
FVC/FEV1 (%)	—0.007	—0.007	—0.017	0.004	0.204
FEF25-75 (%)	—0.002	—0.001	—0.004	—0.004	0.938
Gestational age
Term	0.177	0.128	—0.073	—0.428	0.166
Preterm	0	0	0	0	—
Birth weight
≥2.5kg	0.704	1.054	1.367	2.769	0.504
<2.5kg	0	0	0	0	—
Meconium ileus
Yes	—0.091	0.122	—0.329	0.147	0.452
No	0	0	0	0	—
Period of exclusive breastfeeding
—	0.028	0.017	0.005	0.061	0.094
Number of hospitalizations
—	—0.101	0.022	—0.144	–0.058	<0.001
Time from 1 st appointment to diagnosis
­—	0.004	0.001	0.001	0.007	0.004
Time between birth and diagnosis
—	0.004	0.001	0.002	0.006	<0.001
Known alleles
1 known allele	—0.023	0.131	—0.280	0.234	0.861
2 known alleles	—0.044	0.146	—0.330	0.242	0.764
No known alleles	0	0	0	0	—
Onset of gastrointestinal symptoms
—	0.002	0.001	—0.001	0.004	0.161
Onset of respiratory symptoms
—	0.004	0.002	0.001	0.007	0.010

H/A, Height/age; FVC (%), forced vital capacity; FEV1 (%), forced expiratory volume in the first second; FEF_25-75 (%), forced expiratory flow between 25-75% of FVC; CI, confidence interval.