Fig. 2.
Whole body gas exchange and respiratory exchange ratio (RER) during peak exercise. A and B: whole body oxygen consumption (V̇o2; A) and carbon dioxide production (V̇co2; B) normalized to body weight (kg) raised to the 0.75 power at baseline (black bars) and at peak exercise (open bars) by indirect calorimetry. C: RER (V̇co2/V̇o2) at baseline and 25, 50, 75, and 100% of peak exercise run duration. For each group/variable (i.e. all data), male mice were used (12 wk, fasted 4 h; n = 26 control, 14 SMAKO, and 15 AAKO). a,bP ≤ 0.05 for baseline group difference; noncorresponding letters are different. c,dP < 0.05 for peak exercise group difference; noncorresponding letters are different. *P < 0.05, effect of exercise; GP < 0.05 for effect of genotype, AAKO > control and SMAKO; TP < 0.05 for effect of time (i.e., baseline compared with peak), all groups.