Fig. 5.

Whole body gas exchange and RER during submaximal endurance exercise. A and B: whole body oxygen consumption (A) and CO₂ production (B) normalized to body weight (kg) raised to the 0.75 power at baseline (black bars) and at peak exercise (open bars) by indirect calorimetry. C: RER (V̇co₂/V̇o₂) at baseline and following the endurance exercise challenge. For each group/variable (i.e. all data), male mice were used (13 wk, fasted 3 h; n = 23 control, 11 SMAKO, and 14 AAKO). ^a,bP ≤ 0.05 for baseline group difference; noncorresponding letters are different. ^c,dP < 0.05 for peak exercise group difference; noncorresponding letters are different. ^GP < 0.05 for genotype, AAKO > control and SMAKO; ^TP < 0.05 for peak compared with baseline.