Table 1.

Effects of dietary salt changes on BP, UV, and serum aldosterone level

	Low Salt		High Salt
	Before	After	Before	After
Weight change, g	24.1 ± 4.1	23.6 ± 4.5*	22.3 ± 3.4	22.6 ± 3.4*
SBP, mmHg	113.9 ± 17.0	114.0 ± 19.4	104.9 ± 13.5	115.4 ± 14.8
UV, ml/24 h	2,078.2 ± 998.1	1,533.4 ± 544.9*	1,687.5 ± 780.5	5,163.6 ± 2,059.7†‡
Serum aldosterone, pg/ml	464.9 ± 161.8	1,349.1 ± 816.2†	320.9 ± 169.3	154.3 ± 97.6*‡
Urinary sodium, μmol	193.4 ± 40.8	7.0 ± 6.4†	202.7 ± 83.3	1,305.9 ± 411.8†‡

Values are means ± SE. The SPAK knockout (KO) mice were fed with either low-salt diet or high-salt diet for 2 wk. Systolic blood pressure (SBP) was measured using tail-cuff technique. Metabolic cage studies were performed before dietary salt change was started and after the completion of 2 wk of dietary challenges. Urine volume (UV) and blood sample were collected and sent out for aldosterone level determination. n = 8;

^*P < 0.05 and

^†P < 0.01, compared with the mice before feeding with special diet.

^‡P < 0.01, compared with mice fed with low-salt diets.