Fig. 6.

Lack of endogenous Fgfr2b ligands signaling during injury (6–11 dpi) did not lead to increased bleomycin-induced lung injury (6–11 dpi). A: all DTG mice tested positive for solFgfr2b transcript at 28 dpi. **Very significant. B: relative weight change in mice that survived until 11 dpi (3/8 STG) and (4/9 DTG). C: compliance. D: hydroxyproline content of accessory and medial lobes. E–F′: low and high magnification of H/E staining of STG control mice at 11 dpi (E and E′) and DTGs fed doxycycline food from 0 to 11 dpi (F and F′). G: quantification of confluent fibrotic areas in H/E stains of left lobes. H–J: no decreases in epithelial marker expression were detected in injured 6 dpi DTG mice vs. STG; qPCR for Sftpc, Scgb1a1, EpCam; corresponding saline controls normalized to 1 (data not shown). Scale bars E and F: 2 mm; E′ and F′: 200 μm.