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Preterm lambs were given inhaled nitric oxide (5–15 ppm) continuously for 3 wk. At the end of 3 wk of continuous inhalation of nitric oxide (iNO), pulmonary vascular resistance (A) and pulmonary arteriole smooth muscle area (B) remained the same as the respective values for preterm lambs that did not inhale nitric oxide (NO iNO) (means ± SD; n = 5/group). Adapted from Ref. 21 with permission of the American Thoracic Society.
