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Effect of a HF diet on gut barrier function in the small (A and B) and large (C and D) intestine. FITC-dextran 4000 (FD4) flux (=paracellular pathway) (A and C) and horseradish peroxidase (HRP) flux (=transcellular pathway) (B and D) was measured ex vivo in Ussing chambers. Values are means ± SE. Two-way ANOVA (P values displayed for diet, time, and interaction), followed by Bonferroni's post hoc test, *P < 0.05, significant difference; n = 5–6/group.
