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. 2015 Mar 19;308(10):G874–G883. doi: 10.1152/ajpgi.00341.2014

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Fig. 8. — Cellular model of CaSR regulation of HCO₃⁻ secretion in colonocytes of rat distal colon. Top: R568 acting via CaSR causes enhancement of HCO₃⁻ secretion in surface epithelial cells by stimulation of luminal Cl⁻-dependent HCO₃⁻ secretion via apical Cl⁻/HCO₃⁻ exchange and stimulation of luminal SCFA-dependent HCO₃⁻ secretion mediated by apical SCFA/HCO₃⁻ exchange. Bottom: CaSR reduces HCO₃⁻ secretion in the crypt epithelial cells through inhibition of a cAMP-dependent HCO₃⁻ secretory process that may involve a 5-nitro-2-(3-phenylpropylamino)benzoic acid/glibenclamide-sensitive apical anion channel such as cystic fibrosis transmembrane conductance regulator (CFTR) and/or a basolateral HCO₃⁻ entry mechanism(s). +, stimulation; -, inhibition.