Table 2.

Effect of transport inhibitors on basal HCO₃⁻ secretion in rat distal colon

	ΔJHCO3, μEq·h−1·cm−2	ΔIsc, μA/cm2
Amiloride, 10 μM, lumen	0.01 ± 0.01 (3)ns	−6.3 ± 1.0 (3)†
Barium, 5 mM, lumen	0.02 ± 0.06 (3)ns	4.7 ± 0.7 (3)†
Bumetanide, 100 μM, serosa	0.03 ± 0.08 (3)ns	−2.3 ± 4.7 (3)ns
DIDS, 100 μM, lumen	−0.08 ± 0.04 (4)*	4.6 ± 3.9 (4)ns
NPPB, 100 μM, lumen	−0.17 ± 0.06 (3)*	−10.2 ± 0.8 (3)†

Data shown are means ± SE (n).

^*P < 0.05;

^†P < 0.01; ns P > 0.05 vs. control (before treatment). DIDS, 4,4′-diisothiocyano-2,2′-stilbenedisulfonic acid; NPPB, 5-nitro-2-(3-phenylpropylamino)benzoic acid.