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. 2015 May 19;6:72. doi: 10.3389/fendo.2015.00072

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Copyright © 2015 De Mello.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram illustrating the role of epigenetic factors, hyperglycemia, aldosterone and heart failure on the expression of renin and angiotensin II in heart cells with consequent disruption of chemical communication and metabolic cooperation.