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. 2015 May 19;5:9691. doi: 10.1038/srep09691

Figure 2. MP attenuated axonal damage and neuronal death after SCI.

Figure 2

(A) In vivo two-photon imaging of axonal dieback after hemisection spinal cord injury. Representative images of axons in the sham group (n = 6) at 30 min, 8 h, 24 h, and 48 h post-surgery. Representative images of axonal dieback in the saline-treated SCI group and the MP-treated SCI group at 30 min, 8 h, 24 h, and 48 h post-injury. Asterisk indicates lesion site. (B) Representative MAP-2 (red) and DAPI (blue) staining reveals the effects of MP on neurons in the saline-treated group and the MP-treated group. Asterisk indicates lesion site. (C) The axonal dieback distance from initial lesion site after hemisection SCI in the saline-treated SCI group (n = 6), the MP-treated SCI group (n = 6) and the sham group (n = 6). Fifteen to twenty axons were measured per animal. Values presented are mean ± SEM. *P < 0.01. Repeated measure ANOVA followed by Fisher's LSD. (D) The number of neurons at the edge of lesion site in saline-treated group (n = 6) and MP-treated group (n = 6). Values presented are mean ± SEM. *P < 0.01, P = 0.007. Statistical comparision was done using Student's t test.