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. 2015 May 19;5:9691. doi: 10.1038/srep09691

Figure 3. MP increased regional microvascular blood flow and reduced microvessel loss after SCI.

Figure 3

(A) Representative image showing axons (green) and blood vessels (red) after hemisection SCI. The yellow square denotes: the monitored microvessel at the edge of lesion site. (B) In vivo two-photon imaging of a microvessel proximal to the lesion site at 30 min, 60 min, 90 min and 120 min post-injury. (C) In vivo two-photon imaging of regional microvascular blood flow from the sham group, saline-treated SCI group and the MP-treated SCI group at 30 min, 60 min, 90 min and 120 min post-injury. (D) Representative images depict blood vessels (red) at the edge of lesion sites in saline-treated group and MP-treated group. Nuclei were stained with DAPI (blue). Asterisk indicates lesion site. (E) Changes of vascular lumen diameter in the sham group (n = 6), saline-treated group (n = 6), and MP-treated group (n = 6) at 30 min, 60 min, 90 min and 120 min post-injury. P > 0.05. (F) Changes of microvascular blood flow velocity in the sham group (n = 6), saline-treated group (n = 6), and MP-treated group (n = 6) at 30 min, 60 min, 90 min and 120 min post-injury. Values presented are mean ± SEM. *P < 0.01. Repeated measure ANOVA followed by Fisher's LSD. (G) The number of microvessels at the edge of lesion site in saline-treated (n = 6) and MP-treated (n = 6) mice. Values presented are mean ± SEM. *P < 0.01. Student's t test.