[Table/Fig-2]:
Changes in lipid profile in normal and alloxan induced diabetic rats before and after treatment with DADS (100mg/kg body weight) for 30 days
| S.No | Parameter | Group I (n=6) | Group II (n=6) | Group III (n=6) | Group IV (n=6) | f-Value | p-Value |
|---|---|---|---|---|---|---|---|
| 1 | Total Lipids(mg/dl) | 164± 18.8a | 265±46.8 b | 163.5±21.08 a | 203.6±23.67c | 14.83 | <0.0001 |
| 2 | Triacylglycerols(mg/dl) | 60±4.0 a | 90±9.1 b | 49.8±6.3 c | 64±7.4 d | 33.09 | <0.0001 |
| 3 | Total Cholesterol(mg/dl) | 58±4.5 a | 100±6.1 b | 53±4.8 a | 77±5.41 c | 89.33 | <0.0001 |
| 4 | Phospholipids(mg/dl) | 31±4.1 a | 66.4±3.8 b | 30.5±3.2 a | 42.6±5.3 c | 83.24 | <0.0001 |
| 5 | Free Fatty acids(mg/dl) | 4.66±0.64 a | 6.96±0.61 b | 4.4±0.3 a | 5.8±0.39 c | 26.35 | <0.0001 |
| 6 | Esterified Fatty acids(mg/dl) | 65±9.74 a | 90.2±9.39 b | 68±16.1 a | 82±12.1 b | 5.149 | 0.0090 |
| 7 | Total Fatty acids(mg/dl) | 69.75±9.2 a | 97.16±9.26 b | 72.4±16.1 a | 87.8±11.82 b | 6.335 | 0.0037 |
| 8 | HDL Cholesterol(mg/dl) | 35±5.08 a | 19±2.3 b | 27.5±4.96 c | 24±7.64 b | 8.470 | 0.0009 |
| 9 | LDL Cholesterol(mg/dl) | 10.3±7.2 a | 63±5.9 b | 15.5±2.2 a | 40.4±5.38 c | 105.7 | <0.0001 |
| 10 | VLDL Cholesterol(mg/dl) | 12.0±0.8 a | 18.0±1.8 b | 9.9±1.2 c | 12.8±1.4 d | 33.09 | <0.0001 |
| Tissue | |||||||
| 1 | Total Lipids(mg/g) | 20±2.3 a | 51±6.9 b | 19.6±6.7 a | 30±4.16 c | 42.17 | <0.0001 |
| 2 | Triacylglycerols(mg/g) | 14±1.7 a | 44±2.9 b | 12.8±3.4 a | 32±8.2 c | 53.33 | <0.0001 |
| 3 | Total Cholesterol(mg/g) | 4.3±0.3 a | 6.1±0.46 b | 3.8±0.52 a | 4.0±0.32 c | 34.67 | <0.0001 |
| 4 | Phospholipids(mg/g) | 0.96±0.21 a | 2.48±0.23 b | 1.0±0.2 a | 1.55±0.36 c | 32.90 | <0.0001 |
Note: Each value is mean ± SD of 6 observations in each group. In each row values with different superscripts (a,b,c,d) are significantly different from each other (p<0.05)