Table 2. Association of SNPs in FGF and FGFR genes with chemotherapeutic response in patients with ovarian cancer.
| SNP | Gene | Position | Nonresponders (ww/wv/vv)a | Responders (ww/wv/vv) | OR (95%CI)b | P | Modelc |
|---|---|---|---|---|---|---|---|
| rs3806929 | FGF18 | 5′ Flanking region | 42/45/9 | 66/92/41 | 0.64 (0.44–0.94) | 0.022 | Addd |
| rs9920722 | FGF7 | Intron | 47/42/7 | 71/99/29 | 0.65 (0.44–0.98) | 0.039 | Add |
| rs12812339 | FGF23 | 5′ Flanking region | 55/34/7 | 92/83/22 | 0.65 (0.43–0.98) | 0.039 | Add |
| rs3733336 | FGF5 | 3′ UTR | 37/49/10 | 71/92/36 | 0.44 (0.19–0.98) | 0.045 | Rec |
a
ww, homozygous for wild-type allele; wv, heterozygous for variant allele; vv, homozygous for variant allele; OR, odds ratio; UTR, untranslated region.
b
Adjusted for age, stage, histology, and treatment
c
Models of inheritance: Add, additive; Dom, dominant; Rec, recessive.
d
Remained significant for >50% of the 1000 bootstrap resamplings.