Table 3. Variants in NLR and inflammasome-related genes, and protein domains affected by them.
| GENE | rs number | Samples | AA change | MAF | Domain |
|---|---|---|---|---|---|
| IPAF (NLRC4) | 149451729 | 2941 | p.G786V | 0.004 | LRR6 |
| NAIP | 61757629 | B7 | p.A161T | 0.02 | BIR2 |
| NLRP1 | 61754791 | 2942 | p.V939M | 0.02 | LLR5 |
| NLRP2 | 142463014 | 2942 | p.S4L | 0.01 | DAPIN |
| novel | B7 | p.G504D | 0 | NACHT | |
| 182098487 | 2940 | p.L607P | 0.005 | between NACHT and LRR1 | |
| NLRP3 | 121908147 | O5 | p.V198M | 0.01 | between DAPIN and NACHT |
| 35829419 | A1,A2 | p.Q703K | 0.05 | between NACHT and LRR1 | |
| NLRP4 | 117212164 | O1,O5 | p.T162M | 0.004 | NACHT |
| NLRP5 | novel | F1 | p.N255S | 0.001 | between DAPIN and NACHT |
| novel | 2940 | p.R274Q | 0.001 | between DAPIN and NACHT | |
| NLRP10 | 150112481 | O1 | p.I384T | 0.001 | NACHT |
| NLRP11 | 11671248 | 2940 | p.S1025L | 0.01 | C-terminal |
| NLRP12 | novel | R1,R2 | p.R211C | 0.001 | NACHT |
| NOD1 (CARD4) | novel | 2942 | p.C241G | 0 | NACHT |
| NOD3 (NLRC3) | novel | 2940 | p.R1005Q | 0 | LRR15 |
| NOD4 | 16965150 | 2941, F1 | p.S210L | 0.03 | before NACHT domain |
| NOD5 (NLRX1) | 150153921 | B7 | p.L193V | 0.007 | NACHT |
| 145779362 | O1,O5 | p.R547W | 0.007 | between NACHT and LRR1 | |
| NWD1 | 149694092 | F1 | p.S306L | 0.006 | between WD and NACHT |
AA: amino acid, MAF: minor allele frequency.